Medical practice
Del Mundo returned to the Philippines in 1941, shortly before the Japanese invasion of the country later that year. She joined the International Red Cross and volunteered to care for children-internees then detained at the University of Santo Tomas internment camp for foreign nationals. She set up a makeshift hospice within the internment camp, and her activities led her to be known as "The Angel of Santo Tomas". After the Japanese authorities shut down the hospice in 1943, del Mundo was asked by Manila mayor León G. Guinto, Sr. to head a children's hospital under the auspices of the city government. The hospital was later expanded into a full-care medical center to cope with the mounting casualties during the Battle of Manila, and would be renamed the North General Hospital (later, the Jose R. Reyes Memorial Medical Center). Del Mundo would remain the hospital's director until 1948.
Del Mundo joined the faculty of the University of Santo Tomas, then the Far Eastern University in 1954. She likewise established a small medical pediatric clinic to pursue a private practice.
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